Endocrine Abstracts

Objective: Cystatin C (CysC) is a marker for estimation of glomerular filtration rate (GFR) and a predictor of mortality, beyond that provided by GFR. CysC increases with abdominal obesity and insulin resistance independently of GFR, not necessarily due to changes in renal clearance but possibly due to changes in production. Non-GFR determinants of CysC remain poorly defined. GH or thyroid hormone excess (acromegaly and hyperthyroidism) lead to concomitant increases in GFR and...

Background, aims: Acromegaly is caused by excessive growth hormone (GH) secretion, usually by a pituitary adenoma. Surgical removal of the GH-producing adenoma is the most effective treatment. Drug treatment is second-line option. Earlier work suggested Soluble (s)Klotho levels to be a supplementary biomarker to IGF-1. We tested whether IGF-1 and sKlotho serum levels show a concomitant reduction under medical treatment. If yes, is the extent of reduction in serum IGF-1 and sKl...

Background: Resistin was originally proposed in animal models as a link between obesity and insulin resistance, but later studies in humans have shown a divergent role. Yet, resistin seems to be involved in the development of atherosclerosis in humans by promoting the formation of foam cells; further, its expression is induced by oxidized low-density lipoproteins (LDL) in human macrophages.Methods: We assessed the relationships between resistin and marke...